There are currently two main classes of antidepressants used to treat melancholy: norepinephrine reuptake inhibitors ; and selective serotonin reuptake inhibitors . The researchers tested eight frequently prescribed antidepressant drugs, including four SSRIs. The SSRI medications tested had been fluoxetine , sertraline , paroxetine and citalopram . In animal models, those in a position to produce norepinephrine experienced behavioral changes when provided the antidepressants. But all of the antidepressants, except citalopram, failed to work in the versions lacking norepinephrine. These outcomes provide striking evidence that norepinephrine plays a critical part for the creation of desired behavioral ramifications of most classes of antidepressant compounds including the SSRIs.Gonzalez, chairman and chief executive officer, AbbVie. Today marks a significant step forward inside our effort to become a innovator in oncology and meaningfully augment our long-term growth strategy. The Pharmacyclics team has built a significant and rapidly growing franchise with significant long-term potential across a variety of hematological cancers. Imbruvica is approved for make use of in four indications in the U.S. And is the only product to have obtained three Breakthrough Therapy designations by the U.S. Drug and Food Administration. As component of a worldwide partnership with Janssen Biotech, Inc., Imbruvica is now approved in nearly 50 countries. Imbruvica is in mid – and late-stage advancement for additional hematological oncology indications, with an increase of than 60 clinical trials underway, including 13 in Phase 3 development.