This result was in keeping with the discovering that delaying gluten publicity until the age of 12 months is safe but will not considerably reduce the threat of islet autoimmunity in children who are genetically at risk for type 1 diabetes.22 Postponing the introduction of gluten had two positive consequences potentially. Initial, it delayed the advancement of celiac disease, which might reduce the negative aftereffect of the disease on vulnerable organs such as the brain. Second, the prevalence was reduced by it, albeit non-significantly, of celiac disease autoimmunity at any age among kids carrying the high-risk HLA genotype .23 The idea of a window of gluten tolerance gained popularity after U.S.Systemic reactogenicity was higher in the RTS,S/AS01 group than in the control group ., and Table S12 in the Supplementary Appendix). Postvaccination fever was reported after 30.6 percent of doses in the RTS,S/AS01 group and after 21.1 percent of doses in the control group. The incidence of mucocutaneous disease was comparable in both study groups . Immunogenicity Before vaccination, 34.3 percent and 35.2 percent of infants in the RTS,S/AS01 and control groups, respectively, were positive for anti-circumsporozoite antibodies but at low titers .