The defect in APECED resides in the autoimmune regulator AIRE, which has a key role in immunotolerance.2 The susceptibility to candida in sufferers with APECED is attributed to autoantibodies to interleukin-17 and interleukin-22,3 since type 17 helper T cells are crucial for mucosal antifungal immunity.4 Little is well known about the defects underlying susceptibility to candida in patients with autosomal dominant CMC.5 In a far more recent study, investigators found defective Th17 responses in sufferers with this disorder. We sought the genetic cause of susceptibility to mucocutaneous fungal illness in family members with autosomal dominant CMC. Methods Study Design The analysis was approved by the ethics committee at Radboud University Nijmegen Medical Center and the Newcastle and North Tyneside research ethics committee.The weaker yen/dollar exchange rate decreased operating revenue per diluted share by $.04 for the fourth quarter. Excluding the impact from the weaker yen, operating earnings per talk about elevated 4.8 percent. For the full year, total revenues were 14 up.4 percent to $25.4 billion, compared with $22.2 billion a 12 months ago. Net revenue were $2.9 billion, or $6.11 per diluted share, compared with $1.9 billion, or $4.12 per share, in 2011. Operating revenue for the full year were $3.1 billion, or $6.60 per diluted share, compared with $2.9 billion, or $6.27 per diluted share, in 2011. Operating income per diluted share rose 5.3 percent for the year. For the year, the yen/dollar exchange rate was flat relatively. Excluding a $.01 per share benefit from the impact from forex, operating income per diluted share rose 5.1 percent for the entire year.