This is accomplished by acquiring genetic profiles greater than 2,000 volunteers in Cincinnati, Kansas City and Atlanta, including Americans of European descent and African Americans. Some of the volunteers had heart failure; others had ischemia; healthful volunteers made up a third group. To deepen their knowledge of the genetic variation, the researchers produced cell lines and created genetically altered mice to predict how the gene would function in human beings.End Points The coprimary end points were the incidence of main adverse cardiac events at thirty days and at 12 a few months after the procedure. The ultimate end point of main adverse cardiac events was a composite of loss of life from any cause, myocardial infarction, do it again coronary revascularization, or stroke. Follow-up clinical assessment of the patients was performed personally at thirty days and at 12 a few months.